Available for individuals with expertise in molecular virology or innate immune signaling. Research focus will involve elucidation of host cellular factors required for viral (influenza, Dengue, West Nile, & HIV) infection, and identification of novel proteins involved in Pattern Recognition Receptor (PRR) signaling. Approaches will exploit large-scale function genomics technologies, including global RNAi analysis, as tools understand the mechanistic implications of these host-pathogen interactions.
Systems & Wet-bench Research.
Projects include using systems-based approaches to:
(i) understand early innate responses to HIV infection (see also http://www.hint.org/)
(ii) dissect innate signaling pathways that response to nucleic acid PAMPs
(iii) elucidate cellular restriction mechanisms of flaviviral replication
(iv) discover host-pathogen interactions that regulate viral replication
(v) develop novel anti-viral therapies
Postdoctoral Positions In Systems Immunology & VIirology
Multiple postdoctoral positions are immediately available in Sanford Burnham Medical Research Institute’s Infectious and Inflammatory Disease Center (IIDC) in the laboratory of Dr. Sumit K. Chanda. Positions will focus on generating a systems-level understanding of immune response pathways including TLRs, cGAS, CD40 and Fc-mediated signaling, as well as host-pathogen interactions of RNA and DNA viruses. Prospective candidates will play an important role in elucidating novel factors involved in the interplay between host innate immune factors and their implication in inflammatory, autoimmune, and infectious disease. Aspects of certain projects will involve collaborations with Pharma R&D teams.
Highly motivated candidates who recently obtained a Ph.D., with a strong background in innate immune signaling or viral evasion mechanisms are encouraged to apply. The ideal candidate will have a deep understanding of the innate immune system including TLR, NLR, and RLR signaling, as well as additional immune pathways induced in myeloid & lymphoid cells, and/or strong experience in molecular virology, cell biology, and biochemistry. An understanding and ability to apply systems level technologies and associated statistical techniques towards the analysis of large data sets are a plus. Candidates must have good communication skills, and should be able to work independently and in a collaborative scientific environment. Successful candidates will have a strong publication record in peer-reviewed journals.
Research Assistant in Molecular Virology
We are seeking a highly self-motivated individual with a strong background in mammalian cell culture and molecular biology. Experience in assay development and high throughput genetic screening is desirable. The candidate will work in a highly dynamic and fast-paced environment to perform basic molecular techniques such as cloning and DNA/RNA/protein purification. Additionally, the candidate will also be involved in cell-based screening, siRNA and cDNA transfections, tissue culture, maintenance of various mammalian cell lines, and other related duties and tasks as required or assigned. Experience in cell-based high throughput assays with automated liquid handlers is highly desired..
The successful candidate must have a BS degree with a minimum of 1 year (and
typically up to 5 years) of directly related experience in an academic or industry setting.
Interested, qualified applicants should email their Curriculum Vitae including names and correspondence of three references to Crystal Herndon, firstname.lastname@example.org..