our goals

Post-Doctoral Positions Available (click here)

 

host-pathogenresearch interests. viruses are obligate pathogens, and therefore their survival is dependent upon their ability to exploit host cellular machinery. concurrently, viruses must also successfully evade immune surveillance mechanisms, including first-line (innate) defense systems. our lab is interested in unraveling the molecular bases for these complex host-pathogen interactions. Specifically, we are studying cellular proteins required for both influenza A and retrovirus/HIV infection. additionally, we are investigating novel molecules that regulate, or respond to, Pattern Recognition Receptor (PRR) signaling. Taken together, we aim to elucidate the repertoire of host proteins required for viral infection, and understand the molecular strategies adapted by these viruses as countermeasures to innate immune responses. to understand these events on a global level, our lab uses a series of systems-level approaches, including genome-wide RNAi, proteomics and protein-protein interaction (PPI) analysis, and high content imaging. These, and other, tools are helping us to build a comprehensive cellular 'roadmap' exploited by these viruses to enable their propagation within a cell. these studies are expected to provide unprecedented insight into the molecular circuitry commandeered by these pathogens to establish infection, and will offer new opportunities for the development of 'next generation' host factor and immune-mediated antivirals.